Sodium Hydroxide → HCID 16784872, compound

HRID 1820717Notes

Reaction equation

HRID 1820717 reaction equation
C([O:3][C:4](=[O:22])[C:5]1[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:6]=1[O:14][C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)C.[OH-].[Na+]>>[F:21][C:18]1[CH:19]=[CH:20][C:15]([O:14][C:6]2[CH:7]=[CH:8][C:9]([N+:11]([O-:13])=[O:12])=[CH:10][C:5]=2[C:4]([OH:22])=[O:3])=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 69037206HCID 69037206, compound

Product 1

HCID 16784872HCID 16784872, compound

Procedure

2-(4-Fluoro-phenoxy)-5-nitro-benzoic acid can be prepared by a similar method to that described in the literature (e.g. WO9938845) by reaction of 2-Chloro-5-nitro-benzoic acid ethyl ester [16588-17-3] with 4-Fluoro-phenol [371-35-7] yielding 2-(4-Fluoro-phenoxy)-5-nitro-benzoic acid ethyl ester. 2-(4-Fluoro-phenoxy)-5-nitro-benzoic acid ethyl ester can then be hydrolysed with sodium hydroxide for example to yield the title compound. MS (m/e): 276.1 (M+H+, 100%).

Sources & evidence

ORD record
ord-cfdbbc054cf143098453a8887a0fac6a
Source dataset
uspto-grants-2009_10
Patent number
US07605163B2

Reaction notes

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