HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1820718Generated: October 25, 2026
tert-Butyl piperazine-1-carboxylate → 4-(4-Cyano-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
https://huagongshe.com/reaction/1820718
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 2,3,4-Trifluorobenzonitrile | HCID 518936 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 4-(4-Cyano-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester | HCID 68840745 | 75.4% |
Reaction Steps
To a solution of N-Boc-piperazine (0.65 g) in DMA (20 mL) was slowly added a solution of 2,3,4-trifluorobenzonitrile (0.49 g) in DMA (10 mL). The reaction mixture was stirred for 2 hours at 80° C. After such time the solvent was removed in vacuo and purified by column chromatography (SiO2) to yield the title compound as white solid (0.76 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07605163B2 |
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| Source dataset | uspto-grants-2009_10 |
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| ORD ID | ord-447324baccc644f1bd4916f4602d6a66 |
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| Source note | uspto-grants-2009_10 |
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