2-(4-Benzylpiperazin-1-yl)-5-trifluoromethylpyrimidine → 2-(Piperazin-1-YL)-5-(trifluoromethyl)pyrimidine

HRID 1820731Notes

Reaction equation

HRID 1820731 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][N:15]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO>[N:11]1([C:14]2[N:15]=[CH:16][C:17]([C:20]([F:22])([F:21])[F:23])=[CH:18][N:19]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

3

Reactant 1

HCID 468388822-(4-Benzylpiperazin-1-yl)-5-trifluoromethylpyrimidine

Product 1

HCID 163147972-(Piperazin-1-YL)-5-(trifluoromethyl)pyrimidineYield 90.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

To a solution of 2-(4-Benzyl-piperazin-1-yl)-5-trifluoromethyl-pyrimidine (0.63 g) in methanol was added Palladium-C (Degussa E101N; 5%), and the reaction mixture was heated at 60° C. under hydrogen atmosphere. The reaction mixture was then allowed to cool down to room temperature, the catalyst was filtered off, and solvent was removed in vacuo to yield the title compound as a colorless solid (0.41 g). MS (m/e): 233.1 (M+H+).

Workup

  1. temperatureto cool down to room temperature
  2. filtrationthe catalyst was filtered off
  3. customsolvent was removed in vacuo

Sources & evidence

ORD record
ord-95ee7e19a4c544118c72b7160c2fde85
Source dataset
uspto-grants-2009_10
Patent number
US07605163B2

Reaction notes

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