Ammonia → HCID 69039443, compound

HRID 1820752Notes

Reaction equation

HRID 1820752 reaction equation
C[O:2][C:3]([C:5]1[N:6]=[CH:7][C:8]([N:11]2[CH2:16][CH2:15][N:14]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH2:13][CH2:12]2)=[N:9][CH:10]=1)=O.[NH3:24]>CO>[C:20]([O:19][C:17]([N:14]1[CH2:15][CH2:16][N:11]([C:8]2[CH:7]=[N:6][C:5]([C:3](=[O:2])[NH2:24])=[CH:10][N:9]=2)[CH2:12][CH2:13]1)=[O:18])([CH3:23])([CH3:22])[CH3:21]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 52987591HCID 52987591, compound

Product 1

HCID 69039443HCID 69039443, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

3 mmol of 2,3,5,6-Tetrahydro-[1,2′]bipyrazinyl-4,5′-dicarboxylic acid 4-tert-butyl ester 5′-methyl ester (example 1.13(a)) was dissolved in a 7 molar solution of gaseous ammonia in methanol. The reaction vessel was tightly closed and heated overnight at 60° C. Cooling of the reaction mixtures led to crystallisation of the title compound. MS (m/e): 308.4 (MH+, 100%)

Workup

  1. customThe reaction vessel was tightly closed
  2. temperatureCooling of the reaction
  3. custommixtures led to crystallisation of the title compound

Sources & evidence

ORD record
ord-9a50a63c6fe84a979fc13251d3dd299d
Source dataset
uspto-grants-2009_10
Patent number
US07605163B2

Reaction notes

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