1-[2-Fluoro-4-(methylsulfonyl)phenyl]piperazine → (2,6-Difluoro-3-methanesulfonyl-phenyl)-[4-(2-fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-methanone

HRID 1820769Notes

Reaction equation

HRID 1820769 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[CH:5]=[CH:4][C:3]=1[N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1.[F:18][C:19]1[C:27]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:26][CH:25]=[C:24]([F:32])[C:20]=1[C:21](O)=[O:22]>>[F:18][C:19]1[C:27]([S:28]([CH3:31])(=[O:29])=[O:30])=[CH:26][CH:25]=[C:24]([F:32])[C:20]=1[C:21]([N:15]1[CH2:16][CH2:17][N:12]([C:3]2[CH:4]=[CH:5][C:6]([S:8]([CH3:11])(=[O:10])=[O:9])=[CH:7][C:2]=2[F:1])[CH2:13][CH2:14]1)=[O:22]

Participants

3

Reactant 2

HCID 27827301-[2-Fluoro-4-(methylsulfonyl)phenyl]piperazineHCID 431409352,6-Difluoro-3-(methylsulfonyl)benzoic acid

Product 1

HCID 69037451(2,6-Difluoro-3-methanesulfonyl-phenyl)-[4-(2-fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-methanone

Procedure

This compound was prepared in analogy to example 5 from 1-(2-fluoro-4-methanesulfonyl-phenyl)-piperazine and 2,6-difluoro-3-methanesulfonyl-benzoic acid. MS (m/e): 477.0 (MH+, 67%)

Sources & evidence

ORD record
ord-6b77b656f51e4f6f807c11afe5d29c1f
Source dataset
uspto-grants-2009_10
Patent number
US07605163B2

Reaction notes

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