4-(Piperazin-1-yl)benzonitrile → 4-[4-(2,6-Difluoro-3-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

HRID 1820770Notes

Reaction equation

HRID 1820770 reaction equation
[N:1]1([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[F:15][C:16]1[C:24]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:23][CH:22]=[C:21]([F:29])[C:17]=1[C:18](O)=[O:19]>>[F:15][C:16]1[C:24]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:23][CH:22]=[C:21]([F:29])[C:17]=1[C:18]([N:4]1[CH2:5][CH2:6][N:1]([C:7]2[CH:8]=[CH:9][C:10]([C:11]#[N:12])=[CH:13][CH:14]=2)[CH2:2][CH2:3]1)=[O:19]

Participants

3

Reactant 2

HCID 27339954-(Piperazin-1-yl)benzonitrileHCID 431409352,6-Difluoro-3-(methylsulfonyl)benzoic acid

Product 1

HCID 690362874-[4-(2,6-Difluoro-3-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile

Procedure

Prepared in analogy to example 5 from 4-piperazin-1-yl-benzonitrile and 2,6-difluoro-3-methanesulfonyl-benzoic acid. MS (m/e): 406.3 (MH+, 84%)

Sources & evidence

ORD record
ord-0a02a56eabf042c99db0a4aa533d2af9
Source dataset
uspto-grants-2009_10
Patent number
US07605163B2

Reaction notes

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