2-Propanol, sodium salt (1:1) → 4-[4-(2-Fluoro-6-isopropoxy-3-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile
Reaction equation
[F:1][C:2]1[C:23]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:22][CH:21]=[C:20](F)[C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)=[O:5].[CH:29]([O-:32])([CH3:31])[CH3:30].[Na+]>>[F:1][C:2]1[C:23]([S:24]([CH3:27])(=[O:25])=[O:26])=[CH:22][CH:21]=[C:20]([O:32][CH:29]([CH3:31])[CH3:30])[C:3]=1[C:4]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:13]=[CH:14][C:15]([C:16]#[N:17])=[CH:18][CH:19]=2)[CH2:8][CH2:7]1)=[O:5]Participants
3
Procedure
The compound was prepared in analogy to example 359 from 4-[4-(2,6-difluoro-3-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzonitrile and sodium isopropanolate. MS (m/e): 446.0 (MH+, 49%)
Sources & evidence
- ORD record
- ord-75324c4344294937a18f3c0f16cda589
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07605163B2
Reaction notes
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