Methanol → 2-Hydroxy-5-methylsulfamoyl-benzoic acid methyl ester

https://huagongshe.com/reaction/1820784

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	1,1'-Carbonyldiimidazole	HCID 68263	—
Reactant	2-Hydroxy-5-methylsulfamoyl-benzoic acid	HCID 14490061	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-Hydroxy-5-methylsulfamoyl-benzoic acid methyl ester	HCID 23046763	—

Reaction Conditions

Temperature	70 °C

Reaction Steps

To 77 mmol 2-hydroxy-5-methylsulfamoyl-benzoic acid in 300 ml THF was added 85 mmol CDI, and the mixture heated at 70° C. for 1 h. 770 mmol methanol was then added, and the mixture was heated at 70° C. for 16 h. The mixture was then cooled to room temperature and concentrated in vacuo. The residue was chromatographed on silica gel (eluant: ethyl acetate/heptane/dichloromethane 45:45:10) to afford the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07605163B2
Source dataset	uspto-grants-2009_10
ORD ID	ord-d580de776b3542dc8b28ee8a8102ce1a
Source note	uspto-grants-2009_10