HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1820798Generated: October 31, 2026
Piperazine → 1-[4-(Ethylsulphonyl)-2-fluorophenyl]piperazine
https://huagongshe.com/reaction/1820798
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 1,2-Difluoro-4-ethylsulfonylbenzene | HCID 26597366 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 1-[4-(Ethylsulphonyl)-2-fluorophenyl]piperazine | HCID 26597587 | — |
Reaction Steps
To 2.0 mmol 4-ethanesulfonyl-1,2-difluoro-benzene in 5 ml N,N-dimethylacetamide was added 5.6 mmol piperazine and the mixture was heated at 80° C. for 45 min. The mixture was then concentrated in vacuo to afford the title compound. MS (m/e): 273.0 (M+H+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07605163B2 |
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| Source dataset | uspto-grants-2009_10 |
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| ORD ID | ord-a02b34ad5d004d4fa64d7288520359ba |
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| Source note | uspto-grants-2009_10 |
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