HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 5-Acetyl-2-isopropoxy-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | Methyl 5-acetylsalicylate | HCID 85444 | — |
| Reactant | Di-tert-butyl azodicarboxylate | HCID 97268 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Acetyl-2-isopropoxy-benzoic acid methyl ester | HCID 69037473 | — |
Reaction Steps
To 25.8 mmol methyl-5-acetyl-2-hydroxybenzoate, 28.3 mmol 2-propanol and 29.6 mmol triphenylphosphine in 100 ml THF was added 28.3 mmol di-tert-butyl azodicarboxylate, and the mixture was stirred at RT for 90 min. The mixture was then concentrated in vacuo to afford the title compound. MS (m/e): 237.1 (M+H+, 100%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07605163B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-aa1c9460451844deab1594d3f6bbd099 |
| Source note | uspto-grants-2009_10 |