Chloroform → [4-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-(2-hydroxy-5-methanesulfonyl-phenyl)-methanone

HRID 1820834Notes

Reaction equation

HRID 1820834 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([S:15]([CH3:18])(=[O:17])=[O:16])=[CH:11][C:10]=1[C:19]([N:21]1[CH2:26][CH2:25][N:24]([C:27]2[CH:32]=[CH:31][C:30]([S:33]([CH3:36])(=[O:35])=[O:34])=[CH:29][C:28]=2[F:37])[CH2:23][CH2:22]1)=[O:20])C1C=CC=CC=1.C(Cl)(Cl)Cl>[Pd].CO>[F:37][C:28]1[CH:29]=[C:30]([S:33]([CH3:36])(=[O:34])=[O:35])[CH:31]=[CH:32][C:27]=1[N:24]1[CH2:23][CH2:22][N:21]([C:19]([C:10]2[CH:11]=[C:12]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:13]=[CH:14][C:9]=2[OH:8])=[O:20])[CH2:26][CH2:25]1

Participants

5

Reactant 2

HCID 6212ChloroformHCID 69037318(2-Benzyloxy-5-methanesulfonyl-phenyl)-[4-(2-fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-methanone

Product 1

HCID 69038724[4-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-(2-hydroxy-5-methanesulfonyl-phenyl)-methanone

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 0.915 mmol (2-benzyloxy-5-methanesulfonyl-phenyl)-[4-(2-fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-methanone, 0.05 mmol palladium on charcoal (10%) in 12.5 ml methanol was hydrogenated at atmospheric pressure at room temperature for 2 hours. After addition of chloroform, the mixture was filtered, and the solvent was evaporated to provide the title compound. MS (m/e): 474.3 (M+NH4+, 100%)

Workup

  1. filtrationthe mixture was filtered
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-dfd2c45602d943ab8762a038aa037a03
Source dataset
uspto-grants-2009_10
Patent number
US07605163B2

Reaction notes

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