Ammonium Chloride → HCID 178419470, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of {[1-bromo-6-(2-phenyl-1,3-thiazol-4-yl)-2-naphthyl]oxy}acetonitrile (277 mg, 0.658 mmol), prepared in the previous step, sodium azide (128 mg, 1.96 mmol) and ammonium chloride (110 mg, 2.05 mmol) in 15 mL of DMF was stirred under nitrogen at 100° C. for 4 h. The reaction was filtered and then 5 mL of 1 N HCl added to the filtrate followed by the addition of 20 mL of water. The solid present was collected by filtration, rinsed with water and dried under reduced pressure to give the title compound (276 mg, 82%) as an off-white solid, mp 227-231° C. Elemental Analysis for C21H14BrN5OS+0.48 C3H7NO+0.47H2O Calc'd: C, 53.07; H, 3.63; N, 15.11. Found: C, 53.08; H, 3.61; N, 14.91.

Provenance & Evidence