HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-nitro-1-(2-pyrrolidin-1-ylethyl)-1H-indole → 5-Amino-1-(2-pyrrolidin-1-ylethyl)indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-nitro-1-(2-pyrrolidin-1-ylethyl)-1H-indole | HCID 11402695 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Amino-1-(2-pyrrolidin-1-ylethyl)indole | HCID 11390574 | — |
Reaction Steps
Prepared analogously to Example VI.1.d from 27.0 g (104 mmol) of 5-nitro-1-(2-pyrrolidin-1-ylethyl)-1H-indole (VII.1.a) in THF as solvent. Yield: 23.2 g (97% of theory); Rf value: 0.50 (silica gel, dichloromethane/methanol/ammonia=9:1:0.1); C14H19N3; EII mass spectrum: m/z=230 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07605176B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-e319f9a028514cdda97f91829d9464c9 |
| Source note | uspto-grants-2009_10 |