Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | 2-(chloromethyl)-6-nitro-1,3-benzoxazole | HCID 2764190 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 68980202 | HCID 68980202 | — |
Reaction Steps
A reaction mixture of 3.00 g (14.1 mmol) of 2-chloromethyl-6-nitrobenzoxazole (VIII.1.a), 1.50 mL (18.0 mmol) of pyrrolidine, and 3.90 g (28.2 mmol) of potassium carbonate in 30 mL of DMF is stirred for 12 hours at 50° C. After this time, the mixture is diluted with water and covered with diethyl ether. The precipitate formed is filtered off and dried at 80° C. Yield: 1.80 g (52% of theory); C12H13N3O3; EII mass spectrum: m/z=248 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07605176B2 |
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| Source dataset | uspto-grants-2009_10 |
|---|
| ORD ID | ord-454940330c804136ac7cdec137e0624f |
|---|
| Source note | uspto-grants-2009_10 |
|---|
