Trifluoroacetic acid → HCID 57892091, compound

Participants

Reaction Steps

0.19 g (0.33 mmol) of N-{4-[2-(4-tert-butoxycarbonylaminopiperidin-1-yl)ethyl]-3-chlorophenyl}-3-biphenyl-4-yl-3-oxopropionamide (compound 1.41) is dissolved in 7 mL of methylene chloride, 500 mL of trifluoroacetic acid is added, and the mixture is stirred for 12 hours at ambient temperature. After this time, saturated sodium hydrogen carbonate solution is added and the precipitate formed is suction filtered. The residue is dried in vacuo over sodium hydroxide. Yield: 160 mg (100% of theory); Rf value: 0.10 (silica gel, methylene chloride/methanol=9:1); m.p. above 144° C. (decomposition); C28H30ClN3O2; EII mass spectrum: m/z=476/478 [M+H]+.

Provenance & Evidence