反应详情

温度

120 °C

1-Benzenesulfonyl-3-(3,4-dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine (5, 290 mg, 0.74 mmol) was dissolved in ethanol (4 mL) and potassium hydroxide pellets (330 mg, 5.9 mmol) were added. The reaction was heated in a CEM Discover microwave instrument at 120° C. for 10 minutes. The reaction mixture was concentrated to dryness and the residue was partitioned between ethyl acetate and saturated sodium bicarbonate. The organic portions were dried with anhydrous magnesium sulfate, filtered and the filtrate concentrated to provide the desired product, 1, which was used without further purification (191 mg). MS(ESI) [M+H+]+=255.1.

1. concentrationThe reaction mixture was concentrated to dryness
2. customthe residue was partitioned between ethyl acetate and saturated sodium bicarbonate
3. dry with materialThe organic portions were dried with anhydrous magnesium sulfate
4. filtrationfiltered
5. concentrationthe filtrate concentrated