HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1820884Generated: October 26, 2026
4-Chlorophenyl Isocyanate → 3-(3,4-Dimethoxy-phenyl)-pyrrolo[2,3-b]pyridine-1-carboxylic acid (4-chloro-phenyl)-amide
https://huagongshe.com/reaction/1820884
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chlorophenyl Isocyanate | HCID 7693 | — |
| Reactant | 3-(3,4-dimethoxy-phenyl)-1H-pyrrolo[2,3-b]pyridine | HCID 11673285 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3,4-Dimethoxy-phenyl)-pyrrolo[2,3-b]pyridine-1-carboxylic acid (4-chloro-phenyl)-amide | HCID 57891706 | 40% |
Reaction Steps
3-(3,4-Dimethoxy-phenyl)-1H-pyrrolo-[2,3-b]pyridine 1 (40 mg, 0.16 mmol) was dissolved in benzene and 4-chlorophenyl isocyanate (36 mg, 0.24 mol) dissolved in tetrahydrofuran (4 mL) was added. 4-Dimethylaminopyridine (20 mg, polymer bound) was added. The reaction was heated in a CEM Discover microwave at 200° C. for 10 minutes. The mixture was filtered and concentrated. The resulting solid was washed with a minimum of methanol, filtered, and then washed with dichloromethane to provide 26, (26 mg, 40%). MS(ESI) [M+H+]+=408.4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07605168B2 |
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| Source dataset | uspto-grants-2009_10 |
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| ORD ID | ord-e5917b7dd6cc4d92b0244fbf9485412b |
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| Source note | uspto-grants-2009_10 |
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