HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Dimethoxyphenylboronic acid → 8-[5-Chloro-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Dimethoxyphenylboronic acid | HCID 2734702 | — |
| Reactant | 3-Bromo-(1-phenylsulfonyl)indole | HCID 2776215 | — |
| Reactant | 3-methylquinoline-8-sulfonyl Chloride | HCID 3574807 | — |
| Reactant | 3-(Cyclopentyloxy)-4-methoxybenzeneboronic acid | HCID 4197993 | — |
| Reactant | HCID 69006690 | HCID 69006690 | — |
| Product | 8-[5-Chloro-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline | HCID 57891745 | — |
Reaction Steps
8-[5-Chloro-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline 95 was prepared using the same protocol as described in Examples 21 and 22, substituting 8-quinoline-sulfonyl chloride, 1-Benzenesulfonyl-3-bromoindole and 3,4-dimethoxyphenyl boronic acid with 3-methyl-quinoline-8-sulfonyl chloride, 1-Benzenesulfonyl-3-bromo-5-chloro-indole and 3-cyclopentyloxy-4-methoxy-phenylboronic acid respectively. MS(ESI) [M+H+]+=547.10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07605168B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-40cee7d49bd44894b607fadfab00dc04 |
| Source note | uspto-grants-2009_10 |