HRID1820898

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2734702

3,4-Dimethoxyphenylboronic acid

C8H11BO4

HCID2776215

1-(Benzenesulfonyl)-3-bromo-1H-indole

C14H10BrNO2S

HCID3574807

3-methylquinoline-8-sulfonyl Chloride

C10H8ClNO2S

HCID4197993

[3-(Cyclopentyloxy)-4-methoxyphenyl]boronic acid

C12H17BO4

结构：COc1ccc2c(c1)c(Br)cn2S(=O)(=O)c1ccccc1

HCID69006720

未命名化合物

PRODUCTS

生成物

结构：COc1ccc2c(c1)c(-c1ccc(OC)c(OC3CCCC3)c1)cn2S(=O)(=O)c1cccc2cc(C)cnc12

HCID57891717

未命名化合物

PROCEDURE

实验过程

8-[5-Methoxy-3-(3-cyclopentyloxy-4-methoxy-phenyl)-indole-1-sulfonyl]-3-methyl-quinoline 97 was prepared using the same protocol as described in Examples 21 and 22, substituting 8-quinoline-sulfonyl chloride, 1-Benzenesulfonyl-3-bromoindole and 3,4-dimethoxyphenyl boronic acid with 3-methyl-quinoline-8-sulfonyl chloride, 1-benzenesulfonyl-3-bromo-5-methoxy-indole and 3-cyclopentyloxy-4-methoxy-phenylboronic acid respectively. MS(ESI) [M+H+]+=543.20.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-462bc5a6e366461baf663af8a2f94fb7
来源数据集: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07605168B2
来源说明: uspto-grants-2009_10

反应 SMILES

C1(S(N2C3C(=CC=CC=3)C(Br)=C2)(=O)=O)C=CC=CC=1.COC1C=C(B(O)O)C=CC=1OC.[CH3:33][C:34]1[CH:35]=[N:36][C:37]2[C:42]([CH:43]=1)=[CH:41][CH:40]=[CH:39][C:38]=2[S:44](Cl)(=[O:46])=[O:45].C1(S([N:57]2[C:65]3[C:60](=[CH:61][C:62]([O:66][CH3:67])=[CH:63][CH:64]=3)[C:59](Br)=[CH:58]2)(=O)=O)C=CC=CC=1.[CH:69]1([O:74][C:75]2[CH:76]=[C:77](B(O)O)[CH:78]=[CH:79][C:80]=2[O:81][CH3:82])[CH2:73][CH2:72][CH2:71][CH2:70]1>>[CH3:67][O:66][C:62]1[CH:61]=[C:60]2[C:65](=[CH:64][CH:63]=1)[N:57]([S:44]([C:38]1[CH:39]=[CH:40][CH:41]=[C:42]3[C:37]=1[N:36]=[CH:35][C:34]([CH3:33])=[CH:43]3)(=[O:46])=[O:45])[CH:58]=[C:59]2[C:77]1[CH:78]=[CH:79][C:80]([O:81][CH3:82])=[C:75]([O:74][CH:69]2[CH2:70][CH2:71][CH2:72][CH2:73]2)[CH:76]=1