Dimethylamine, hydrochloride → HCID 178484563, compound

Participants

Reaction Steps

trans-4-{[(2-{[(5-Chloropyridin-2-yl)amino]-carbonyl}benzofuran-3-yl)amino]carbonyl}cyclohexane-carboxylic acid (176 mg) obtained in Example 8(2) is suspended in pyridine (8 ml), and thereto are added successively dimethylamine hydrochloride (65 mg), 1-hydroxybenzotriazole (108 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (153 mg) under ice-cooling, followed by stirring at room temperature for 19 hours. To the reaction solution is poured ice-water and the precipitates are collected by filtration. The resulting precipitates are dissolved in chloroform and dried over sodium sulfate. After evaporating the solvent under reduced pressure, the residue is purified by NH-silica gel column chromatography (eluent: ethyl acetate) The resulting residue is suspended in n-hexane and the precipitates are collected by filtration to give the title compound (137 mg). APCI-MS M/Z:469/471[M+H]+

Provenance & Evidence