3-Bromo-4-hydroxybenzoic acid → Methyl 3-bromo-4-hydroxybenzoate

Participants

Reaction Steps

A solution of 3.9 g (18.0 mmol) of 3-bromo-4-hydroxybenzoic acid in 20 mL of 3:1 v/v CH2Cl2/CH3OH was treated with 10.8 mL of 2.0 M (trimethylsilyl)diazomethane solution in hexanes. The mixture was stirred at rt for 2 h, then concentrated to give 4.6 g of the title compound: 1H NMR (500 MHz, CDCl3) δ 3.90 (s, 3H), 5.93 (bs, 1H), 7.05 (d, J=8.5, 1H), 7.92 (dd, J=2.1, 8.5, 1M), 8.19 (d, J=2.0, 1H).

Provenance & Evidence