Ethanol → Ethyl 6-hydroxy-5-iodonicotinate

Participants

Reaction Steps

A suspension of 4.6 g (17.36 mmol) of 5-iodo-6-hydroxynicotinic acid and 7.0 mL of concentrated sulfuric acid in 40 mL of ethanol was refluxed for 16 h. The reaction mixture was cooled to rt and filtered to afford 3.0 g of a white solid as the title compound: 1H NMR (500 MHz, DMSO) δ 1.25 (t, J=6.9, 3H), 4.21 (q, J=6.6, 2H), 8.05 (d, J=1.4, 1H), 8.33 (d, J=1.3, 1H).

Provenance & Evidence