Trifluoroacetic acid methylene chloride → HCID 11689680, compound

Participants

Reaction Steps

A solution of 23 mg (0.05 mmol) of tert-butyl 3-(4-(5-(3-cyano-4-isopropyloxyphenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate (from Step A) in 4:1 v/v CH2Cl2/TFA was stirred at rt for 30 min. The mixture was concentrated. Purification by HPLC B gave 17 mg of the title compound: 1H NMR (500 MHz, CDCl3) δ 1.47 (d, J=6.2, 6H), 2.66 (s, 3H), 2.74 (t, J=7.8, 2H), 3.01 (t, J=7.8, 2H), 4.76-4.82 (m, 1H), 7.11 (d, J=9.0, 1H), 7.19-7.21 (m, 2H), 8.01 (d, J=8.3, 1H), 8.33 (dd, J=2.3, 8.9, 11H), 8.42 (d, J=2.1, 1H).

Provenance & Evidence