Sodium Hydroxide → HCID 68890341, compound

Participants

Reaction Steps

To a solution of 33 mg (0.07 mmol) of methyl 3-(4-(3-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-3-methylphenyl)propanoate (from Step D) in 2.0 mL of EtOH was added 200 μL (1.0 mmol) of 5.0 N NaOH. The mixture was stirred at rt overnight. Purification by HPLC B gave 22 mg of the title compound: 1H NMR (500 MHz, CD3OD) δ 1.40 (d, J=6.0, 6H), 2.66 (t, J=7.7, 2H), 2.74 (s, 3H), 2.99 (t, J=7.6, 2H), 4.87 (m, 1H), 7.28-7.37 (m, 3H), 8.06 (d, J=8.0, 1H), 8.30-8.31 (m, 2H).

Provenance & Evidence