HCID 68889341, compound → HCID 69072396, compound

HRID 1821001Notes

Reaction equation

HRID 1821001 reaction equation
[F:1][C:2]([F:35])([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH:27]([CH3:29])[CH3:28])=[C:22]([C:30]([F:33])([F:32])[F:31])[CH:21]=3)[CH2:18][O:17][N:16]=2)=[C:11]([CH3:34])[CH:10]=1)[C:3]([O:5]CC)=[O:4].C(OC1C=CC(C2N=C(C3C=CC(CCC(OC)=O)=CC=3C)ON=2)=CC=1C(F)(F)F)(C)C>>[F:35][C:2]([F:1])([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH:27]([CH3:29])[CH3:28])=[C:22]([C:30]([F:31])([F:32])[F:33])[CH:21]=3)[CH2:18][O:17][N:16]=2)=[C:11]([CH3:34])[CH:10]=1)[C:3]([OH:5])=[O:4]

Participants

3

Reactant 2

HCID 68889341HCID 68889341, compoundHCID 68890408HCID 68890408, compound

Product 1

HCID 69072396HCID 69072396, compound

Procedure

The title compound was prepared using the procedure analogous to that described for EXAMPLE 75 substituting ethyl 2,2-difluoro-3-(4-(4-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)-3-methylphenyl)propanoate (from Step A) for methyl 3-(4-(3-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)-3-methylphenyl)propanoate in Step E: 1H NMR (500 MHz, CD3OD) δ 1.41 (d, J=5.9, 6H), 2.64 (s, 3H), 3.45 (t, J=16.7, 2H), 4.92 (m, 1H), 7.29-7.32 (m, 2H), 7.43 (d, J=8.4, 1H), 8.01 (d, J=7.8, 1H), 8.38-8.40 (m, 2H).

Sources & evidence

ORD record
ord-7d7bd25c0cd84c228741ab582c03fd6d
Source dataset
uspto-grants-2009_10
Patent number
US07605171B2

Reaction notes

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