Hydrogen Peroxide → HCID 86623632, compound

Participants

Reaction Steps

To an ice-cold solution of methyl (R)-(5-formyl-4-methyl-indan-1-yl)acetate (872 mg, 3.76 mmol, from Step C), NaH2PO4 (150 mg) and 30% H2O2 (500 μL) in acetonitrile (10 mL) and H2O (2.5 mL), a solution of NaClO2 (615 mg) in H2O (4 mL) was added dropwise and the reaction mixture was allowed to warm to ambient temperature over 1 hr. After another hour, NaHSO3 (1.0 g) was added and the mixture was partitioned between EtOAc (30 mL) and 2.0 N HCl (15 mL). The layers were separated and the organic layer was washed with H2O (2×15 mL), brine (1×15 mL) dried (MgSO4) and filtered. The filtrate was concentrated in vacuo to give 854 mg of the title compound as a white solid: 1H NMR (500 MHz, CDCl3) δ 1.74-1.82 (m, 1H), 2.40-2.50 (m, 2H), 2.56 (s, 3H), 2.78 (dd, 1H, J=5.5, 15.5 Hz), 2.82-2.93 (m, 1H), 2.94-2.99 (m, 1H), 3.61-3.66 (m, 1H), 3.73 (s, 3H), 7.07 (d, 1H, J=7.8 Hz), 7.89 (d, 1H, J=8.0 Hz), 10.8-12.0 (br, s 1H); HPLC A: rt=2.74 min, m/z=249 (M+H)+.

Provenance & Evidence