Bromine → HCID 11463747, compound

Participants

Reaction Conditions

Reaction Steps

To a solution containing 1.00 g (2.32 mmol) of 8 in 25 mL of anhydrous CH2Cl2 at 0° C. under argon was added 0.50 g (0.16 mL, 3.14 mmol) of Br2. The reaction mixture was stirred at 0° C. for 1 h. The reaction mixture was diluted with 20 mL of CH2Cl2 and washed with 100 mL of 3% aq NaHSO3. The organic layer was separated, dried (MgSO4) and concentrated under diminished pressure. The residue was then purified by flash chromatography on a silica gel column (26×4 cm).

Provenance & Evidence