Hydrazine → HCID 66756046, compound

HRID 1821068Notes

Reaction equation

HRID 1821068 reaction equation
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH:16]=[CH:17][CH2:18][N:19]2C(=O)C3C(=CC=CC=3)C2=O)[CH2:11][CH2:10]1.NN>C(O)C>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][CH:5]=[CH:4][C:3]=1[N:9]1[CH2:10][CH2:11][N:12]([CH2:15][CH:16]=[CH:17][CH2:18][NH2:19])[CH2:13][CH2:14]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 66756624HCID 66756624, compound

Product 1

HCID 66756046HCID 66756046, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2-{4-[4-(2,3-Dichloro-phenyl)-piperazin-1-yl]-but-2-enyl}-isoindole-1,3-dione (5.12 g, 11.9 mmol) in absolute ethanol (100 ml) under an atmosphere of argon was added hydrazine (0.75 ml, 24 mmol), and the reaction mixture was refluxed for 2.5 h. The ice-cold reaction mixture was filtered and solvent was removed under reduced pressure. The residue was purified by column chromatography to yield 2.63 g (74%) as yellow oil.

Workup

  1. temperaturethe reaction mixture was refluxed for 2.5 h
  2. filtrationwas filtered
  3. customsolvent was removed under reduced pressure
  4. customThe residue was purified by column chromatography
  5. customto yield 2.63 g (74%) as yellow oil

Sources & evidence

ORD record
ord-f1928cecf6fb4505ba559b290b3ad1cb
Source dataset
uspto-grants-2009_10
Patent number
US07605259B2

Reaction notes

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