2-Thiopheneacetyl chloride → n-{4-[1-Ethyl-4-(1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-pyrazol-3-yl]phenyl}-2-(2-thienyl)acetamide

HRID 1821190Notes

Reaction equation

HRID 1821190 reaction equation
[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[NH:14][CH:15]=[CH:16][C:9]=23)[C:5]([C:17]2[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=2)=[N:4]1)[CH3:2].[CH:24]1[CH:28]=[C:27]([CH2:29][C:30](Cl)=[O:31])[S:26][CH:25]=1>>[CH2:1]([N:3]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[C:10]3[NH:14][CH:15]=[CH:16][C:9]=23)[C:5]([C:17]2[CH:23]=[CH:22][C:20]([NH:21][C:30](=[O:31])[CH2:29][C:27]3[S:26][CH:25]=[CH:24][CH:28]=3)=[CH:19][CH:18]=2)=[N:4]1)[CH3:2]

Participants

3

Reactant 2

HCID 1623622-Thiopheneacetyl chlorideHCID 689998134-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]aniline

Product 1

HCID 58980032n-{4-[1-Ethyl-4-(1h-pyrrolo[2,3-b]pyridin-4-yl)-1h-pyrazol-3-yl]phenyl}-2-(2-thienyl)acetamide

Procedure

Following the procedure described in Example 1 with 4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]aniline and thiophene-2-acetyl chloride provided the title compound. ESMS [M+H]+: 428.4

Sources & evidence

ORD record
ord-563c6efaf359471a96a0249b5533eb94
Source dataset
uspto-grants-2009_10
Patent number
US07605266B2

Reaction notes

Loading…