化工社化工社 化学情報印刷レポート · 研究参考用
Bromine → 5-Bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | 2-Methyl-4-(4-nitrophenyl)thiazole | HCID 193689 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 5-Bromo-2-methyl-4-(4-nitrophenyl)-1,3-thiazole | HCID 68998100 | 60% |
反応手順
Bromine (6 mmol) was added dropwise to a solution of 2-methyl-4-(4-nitrophenyl)-1,3-thiazole (5 mmol) in chloroform (20 mL) and the solution refluxed for 4 h. The solvent was evaporated and the product purified by crystallization from ether to afford the title compound (60%). ESMS [M+H]+: 300.2
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07605266B2 |
| 出典データセット | uspto-grants-2009_10 |
| ORD ID | ord-e8195c7a25854e70aed3bd5ac738f1f9 |
| 出典メモ | uspto-grants-2009_10 |