Ethyl isocyanate → (E)-1-ethyl-3-{2-[2-(1H-indazol-3-yl)vinyl]phenyl}urea

Participants

Reaction Steps

A solution of (E)-2-[2-(1H-indazol-3-yl)vinyl]phenylamine (60 mg, 0.26 mmol) in THF (1.5 mL) was added with triethylamine (11 μL, 0.08 mmol) and ethyl isocyanate (40.3 μL, 0.51 mmol), followed by stirring at room temperature for 5 hours. Further, the reaction mixture was added with potassium carbonate, stirred for 30 minutes and added with water. The precipitated solid was collected by filtration and the solid was triturated in ethanol to obtain Compound 21 (53 mg, 68%).

Provenance & Evidence