Ethanol → HCID 69002196, compound

Participants

Reaction Conditions

Reaction Steps

Compound 51 (1.5 g, 3.84 mmol), iron powder (4.3 g, 76.8 mmol) and ammonium chloride (616 mg, 11.52 mmol) were added with ethanol (10.0 mL) and water (10.0 mL) at room temperature, stirred at 50° C. for 7 hours and the reaction mixture was filtered through celite. The filtrate was extracted with ethyl acetate and the organic layer was sequentially washed with water and saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was triturated in a mixed solvent of chloroform/ethyl acetate to obtain Compound 56 (724 mg, 52%).

Provenance & Evidence