Sodium Hydroxide → HCID 68997025, compound

Participants

Reaction Conditions

Reaction Steps

(E)-2-chloro-N-{2-[2-(1H-indazol-3-yl)vinyl]phenyl}-4-nitrobenzamide (60 mg, 0.14 mmol) was dissolved in acetic acid (1.0 mL) and hydrochloric acid (0.5 mL). The solution was added with tin(II) chloride (114 mg, 0.6 mmol), stirred at 40° C. for 2 hours, added with 6 mol/L sodium hydroxide to neutralize and then the mixture was extracted with ethyl acetate. The organic layer was sequentially washed with water and saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was triturated in ethanol to obtain Compound 84 (21 mg, 38%).

Provenance & Evidence