Hydrochloric Acid → HCID 68999740, compound

Participants

Reaction Conditions

Reaction Steps

Compound 86 (150 mg, 0.36 mmol) was dissolved in ethanol (2 mL), and the solution was added with tin (92 mg, 0.77 mmol) and concentrated hydrochloric acid (1.0 mL) under ice-cooling, followed by stirring at 40° C. for 1 hour. To the reaction mixture, 6 mol/L sodium hydroxide was added to neutralize the mixture under ice-cooling. Then, the mixture was filtered. The filtrate was added with saturated aqueous sodium hydrogencarbonate solution and extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was triturated in ethyl acetate/methanol(4/1) to obtain Compound 87 (110 mg, 79%).

Provenance & Evidence