Potassium Carbonate → HCID 68999756, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (E)-3-[2-(2-bromophenyl)vinyl]indazole-1-carboxylic acid tert-butyl ester (0.23 g, 0.57 mmol) obtained in Step 2 in toluene (1.5 mL), 1-acetylpiperazine (0.15 g, 1.1 mmol), potassium carbonate (0.20 mg, 1.4 mmol), dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphane (0.068 g, 0.14 mmol) and tris(dibenzylideneacetone)dipalladium (0.052 g, 0.57 mmol) were sequentially added and, the mixture was stirred at 121° C. for 10 minutes under microwave (300 W) irradiation. The reaction mixture was added with water and ethyl acetate to separate the mixture into organic layer and aqueous layer and the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=90/10 to 50/50) to obtain (E)-3-{2-[2-(4-acetylpiperazin-1-yl)phenyl]vinyl}indazol-1-carboxylic acid tert-butyl ester (0.042 g, 17%).

Provenance & Evidence