Sodium Bicarbonate → HCID 69002059, compound

Participants

Reaction Steps

A solution of (E)-3-{2-[2-(4-acetylpiperazin-1-yl)phenyl]vinyl}indazole-1-carboxylic acid tert-butyl ester (41 mg, 0.094 mmol) obtained in Step 3 in ethyl acetate (1.5 mL) was added with 4.0 mol/L hydrogen chloride-ethyl acetate solution (0.082 mL, 0.32 mmol) and stirred at room temperature for 2.0 hours, followed by stirring under heating and reflux for 2.0 hours. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate solution and ethyl acetate to separate the mixture into organic layer and aqueous layer and the aqueous layer was extracted with ethyl acetate 2 times. All organic layers were gathered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform/methanol=90/10) to obtain Compound 133 (13 mg, 41%).

Provenance & Evidence