Hydrochloric Acid → HCID 68999265, compound

Participants

Reaction Conditions

Reaction Steps

Compound 157 (0.10 g, 0.25 mmol) was dissolved in acetic acid (1.0 mL) and hydrochloric acid (1.0 mL) and the solution was added with tin(II) chloride (0.10 g, 0.5 mmol), followed by stirring at 40° C. for 2 hours. Then, the reaction mixture was neutralized by adding 6 mol/L sodium hydroxide and extracted with ethyl acetate. The organic layer was sequentially washed with water and saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was triturated in ethanol to obtain Compound 158 (46 mg, 50%).

Provenance & Evidence