Phthalic Anhydride → (E)-2-{2-[2-(1H-indazol-3-yl)vinyl]phenyl}isoindole-1,3-dione

Participants

Reaction Conditions

Reaction Steps

Compound 2 (0.06 g, 0.25 mmol) was dissolved in xylene (2.0 mL) and the solution was added with phthalic anhydride (83 mg, 0.56 mmol) and triethylamine (89 μL, 0.64 mmol), followed by stirring at 60° C. for 2 hours. Then, the reaction mixture was extracted with ethyl acetate. The organic layer was sequentially washed with water and saturated brine, dried over anhydrous magnesium sulfate and the solvent was evaporated under reduced pressure. The residue was triturated in ethanol to obtain Compound 159 (4.0 mg, 4%).

Provenance & Evidence