Water → HCID 86628203, compound

Participants

Reaction Steps

A solution of Compound 2 (0.06 g, 0.26 mmol) in acetone mL) was added with benzoyl isothiocyanate (0.10 mL, 1.5 mmol), followed by stirring at room temperature for 1 hour. The crude product obtained by adding water to the mixture was collected by filtration, dissolved in ethanol (1 mL) and added with 1 mol/L aqueous sodium hydroxide solution (1 mL), followed by stirring at room temperature for 1 hour. The mixture was neutralized by adding 6 mol/L hydrochloric acid and the precipitated solid was collected by filtration. The residue was triturated in ethanol to obtain Compound 161 (54 mg, 72%).

Provenance & Evidence