Water → HCID 69000538, compound

HRID 1821356Notes

Reaction equation

HRID 1821356 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3](/[CH:10]=[CH:11]/[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[NH2:18])=[N:2]1.CO[CH:21]1[CH2:25][CH2:24][CH:23](OC)O1.O>C(O)(=O)C>[N:18]1([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=2/[CH:11]=[CH:10]/[C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][N:2]=2)[CH:21]=[CH:25][CH:24]=[CH:23]1

Participants

5

Reactant 3

HCID 962WaterHCID 790982,5-DimethoxytetrahydrofuranHCID 69001756HCID 69001756, compound

Product 1

HCID 69000538HCID 69000538, compoundYield 20%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Compound 2 (0.060 g, 0.25 mmol) was dissolved in acetic acid (1.0 mL) and the solution was added with 2,5-dimethoxytetrahydrofuran (99 μL, 0.77 mmol), followed by stirring at room temperature for 2 hours. Then, to the reaction mixture, water was added and the precipitated solid was filtered. The solid was recrystallized from ethanol to obtain Compound 162 (14 mg, 20%).

Workup

  1. filtrationthe precipitated solid was filtered
  2. customThe solid was recrystallized from ethanol

Sources & evidence

ORD record
ord-158a5d8552e04739aa79f8b542d3ae4b
Source dataset
uspto-grants-2009_10
Patent number
US07605272B2

Reaction notes

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