Trifluoroacetic acid → HCID 69002178, compound

Participants

Reaction Steps

A solution of (E)-3-{2-[2-(2-pyridylamino)phenyl]vinyl}-1-(tetrahydropyran-2-yl)-1H-indazole (49 mg, 1.2 mmol) obtained in Step 2 and trifluoroacetic acid (1.0 mL) in methanol (0.50 mL) was stirred at room temperature for 18 hours. A 2 mol/L aqueous sodium hydroxide solution was added to neutralize the mixture and the reaction mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform to chloroform/methanol=97/3) to obtain Compound 164 (10 mg, 50%).

Provenance & Evidence