Water → HCID 86628208, compound

Participants

Reaction Steps

Compound 169 (73 mg, 0.19 mmol) was dissolved in methanol (1.0 mL) and 2 mol/L sodium hydroxide (1.0 mol) was added, followed by stirring at room temperature for 1.5 hours. Water was added to the mixture and the organic layer was extracted with ethyl acetate and the aqueous layer was neutralized using 6 mol/L hydrochloric acid. The precipitated solid was triturated in ethyl acetate to obtain Compound 170 (14 mg, 21%).

Provenance & Evidence