Dichloromethane → HCID 86628209, compound

Participants

Reaction Steps

Compound 169 (0.04 g, 0.10 mmol) was dissolved in THF (1.0 mL) and methylene chloride (1.0 mL) and after cooling to −78° C., diisobutylaluminum hydride (0.95 mol/L toluene solution, 0.65 mL, 0.62 mmol) was added and stirred in a temperature between −78° C. to room temperature for 19 hours. Saturated aqueous Rochelle salt solution was added to the mixture and the organic layer was extracted with ethyl acetate. The organic layer was concentrated and the residue was purified by silica gel column chromatography (chloroform/methanol=9/1). Then, the mixture was triturated in ethanol to obtain Compound 173 (16 mg, 44%).

Provenance & Evidence