Acetic Acid → HCID 69001475, compound

Participants

Reaction Steps

Compound 167 (0.08 g, 0.26 mmol) was dissolved in dichloroethane (2.0 mL) and the solution was added with morpholine (67 μL, 0.77 mmol), acetic acid (84 μL, 0.77 mmol) and sodium borohydride (0.16 g, 0.77 mmol) followed by stirring at room temperature for 30 minutes. The reaction mixture was extracted with ethyl acetate, the organic layer was concentrated and the residue was purified by silica gel column chromatography (chloroform/methanol=9/1) to obtain Compound 182 (0.04 g, 41%).

Provenance & Evidence