3,4,5,6-Tetrahydrophthalic anhydride → HCID 68997521, compound

Participants

Reaction Steps

To a solution of Compound 2 (50 mg, 0.21 mmol) in acetic acid (1.0 mL), 4,5,6,7-tetrahydroisobenzofuran-1,3-dione (39 mg, 0.26 mmol) was added followed by heating under reflux for 1.0 hour. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate solution, extracted with ethyl acetate and the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform to chloroform/methanol=90/10) and crystallized from ethyl acetate to obtain Compound 203 (37 mg, 46%).

Provenance & Evidence