Water → HCID 68999942, compound

Participants

Reaction Steps

To a solution of Compound 2 (0.10 g, 0.43 mmol) in THF (2.0 mL), pyridine (0.10 μL, 1.3 mmol) and 2,3-pyridinedicarboxylic anhydride (76 mg, 0.51 mmol) were added and stirred at room temperature for 1.5 hours. The reaction mixture was added with water, extracted with ethyl acetate and the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform to chloroform/methanol=90/10), crystallized from ethyl acetate to obtain (E)-2-{2-[2-(1H-indazol-3-yl)vinyl]phenylcarbamoyl}nicotinic acid or (E)-3-{2-[2-(1H-indazol-3-yl)vinyl]phenylcarbamoyl}pyridine-2-carboxylic acid (63 mg, 39%).

Provenance & Evidence