Sodium Bicarbonate → HCID 68998965, compound

Participants

Reaction Steps

(E)-(3-{2-[2-(1H-indazol-3-yl)vinyl]phenyl}ureido)oxoacetic acid ethyl ester (50 mg, 0.14 mmol) obtained in Step 1 was heated under reflux in a mixed solvent of 6.0 mol/L hydrochloric acid/acetone (1/1, 2.5 mL) under nitrogen atomosphere for 60 hours. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate solution, extracted with ethyl acetate and the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform to chloroform/methanol=90/10) to obtain Compound 212 (38 mg, 87%).

Provenance & Evidence