Ethyl Acetate → HCID 69002322, compound

Participants

Reaction Steps

Compound 108 (0.30 g, 0.77 mmol) was dissolved in DMF (12 mL) and the solution was added with triphenylphosphine (0.45 g, 1.5 mmol) and carbon tetrabromide (0.51 g, 1.5 mmol), followed by stirring at room temperature for 1 hour. After the reaction, the mixture was added with ethyl acetate and washed with saturated aqueous sodium hydrogencarbonate solution. The organic layer was concentrated under reduced pressure to obtain (E)-N-{2-[2-(1H-indazol-3-yl)vinyl]-5-(bromomethyl)phenyl}-3-methylthiophene-2-carboxamide.

Provenance & Evidence