Triethylamine → HCID 68996976, compound

Participants

Reaction Steps

2-[2-(1H-indazol-3-yl)vinyl]-4-(morpholin-4-yl)phenylamine (0.30 g, 0.94 mmol) synthesized in Example 225 was dissolved in THF (10 mL) and the solution was added with triethylamine (0.40 mL, 2.9 mmol) and N-methylpyrrolecarbonyl chloride (0.41 g, 2.8 mmol), followed by stirring at room temperature for 1 hour. The reaction mixture was added with saturated aqueous sodium hydrogencarbonate solution, extracted with ethyl acetate and the organic layer was concentrated under reduced pressure to obtain free base of Compound 226. Further, said free base was treated by 4 mol/L hydrogen chloride-methanol solution (1.0 mL) to obtain Compound 226 (0.23 g, 49%).

Provenance & Evidence