反应详情

A solution of the 2-amino-3-(bromomethyl)-5-bromopyridine hydrobromide salt (prepared above) in 40% aqueous methylamine (50 mL) and THF (50 mL) was stirred at RT overnight in a pressure bottle. The reaction solution was concentrated and extracted with EtOAc (2×100 mL). The combined organic phases were washed with H2O, dried over Na2SO4 and concentrated. Purification on silica gel afforded the title compound (4.25 g, 80%) as a yellow oil: MS (ES) m/e 217 (M+H)+.

1. concentrationThe reaction solution was concentrated
2. extractionextracted with EtOAc (2×100 mL)
3. washThe combined organic phases were washed with H2O
4. dry with materialdried over Na2SO4
5. concentrationconcentrated
6. customPurification on silica gel